IMMUNE 3D ® is a unique and proprietary platform customized to capture the human cellular microenvironment best suited to screen or discover drug candidates that impact. T cell migration and their effector functions. T cell migration is governed by mechanisms that regulate the activation state of the cell and for environment-specific cues. A number of factors including chemokines, stromal factors and matrix metalloproteinases have been shown to influence the infiltration of T cells in the tumor microenvironment (TME). The migration and infiltration of T cells is critical for effective antitumor immune surveillance. Studies have shown that T cells accumulate in the stroma and the density of stroma extracellular matrix plays a role in controlling migration of lymphocytes.