Cytotoxic T cell (CTL) assay with Keytruda (anti-PD1)
$9,000.00Description
The cytotoxic T Lymphocyte (CTL) response is recognized as perhaps the most relevant functional measure that reflects cell-mediated acquired immune defense against viral infections and cancer. The CTL responses can evaluate effective antigen presentation by tumors and is a key assessment in how well a drug candidate enhances CTL responses in eradicating or killing tumors. This assay utilizes our proprietary HLA-matched CTL and tumor cell lines and is run in a 96 well format.
What is the assay setup?
- Co-culture tumor and CTL for 24 hours in the presence of drug candidate
- After 24 hours harvest the supernatants
- Measure cytokine release and tumor lysis
What are the study arms?
- CTL + Tumor+ Keytruda (anti-PD1)
- CTL + Tumor+ <drug candidate (per dose)>
- CTL + Tumor
- CTL + Tumor + DMSO
- CTL
- Tumor
How many doses are included?
The assay is run in a 96 well plate and can accommodate up to 40 doses of the drug candidate. Each dose is a well.
What is included the price?
- Multiplex cytokine readouts – IL-2, IL-6, IL-4, IL-5, IL-9 IL-10, IL-13,IL-17, TNF-α, IFN-γ
- Assay setup and methods used
- Raw data files for cytokines
When can I expect results?
We project results are available in 2-3 weeks. We can accelerate results on a case-by-case basis. Contact us and we can work with you to accommodate your requests.