Keytruda Resistant TIL and Tumor Platform

Keytruda (anti-PD1) TIL 004 and Tumor 004

Targeting immune regulatory checkpoints such as CTLA4 and PD-1/PD-L1 axis is the leading the field of cancer immunotherapy. However, these immunotherapies fail to control cancer in a significant number of patients. To study these number of factors that lead to resistance requires the appropriate set of “tools”.
We have procured a unique Keytruda (anti-PD1) resistance Tumor Infiltrating Lymphocyte (TIL) and matching cell line from a melanoma patient that did not respond to Keytruda therapy. This TIL/tumor combination has been well characterized with T cell markers including known checkpoints and tumor markers. In addition, we have characterized the sub-populations of TIL for immunosuppressive populations.

TIL 004

PD-1, TIM-3, 4-1BB, CTLA-4, CD45, CD27, OX-40

Tumor 004

4-1BBL, HVEM, CD112, CD155, CD44, CD49a(α1 integrin), CD49b (α2 integrin), CD29(β1 integrin), CD95 (FAS)

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