We continuously develop and procure new assay formats that accelerate drug function and mechanism.
Although 3D tumor spheroids are widely used for drug screening, not all tumors create spheroids. We have partnered with to screen drug candidates using a unique, physiologically relevant 3D platform that captures the components of the tumor immune micro-environment (TIME).
We have conducted a number of studies using our HLA-matched cell platforms such as:
Evaluation of stromal factors involved in CTL cell migration and infiltration.
Evaluating immuno-suppressive mechanisms such as TAMs, Tregs and MDSCs
Hypoxic and metabolic factors
Antigen enhancement upon treatment with drug candidate